Endocrine Physiology 7

1. Name the growth hormone secretagogue that is mainly secreted by the stomach.

Ghrelin

2. In this type of dwarfism in children, plasma GH is normal but GH receptors are unresponsive to GH. What is this condition?

GH insensitivity / Laron dwarfsm

3. In African pygmies, GH level and GH binding protein are normal. What is the defect for their short stature?

IGF-I level fails to increase in response to GH

4. What is Kaspar Hauser syndrome?

Psychosocial dwarfism, chronic abuse

5. An autosomal condition where dwarfism is characterized by short limbs with normal trunk. What is this condition?

Achondroplasia

6. Name the syndrome that results due to postpartum haemorrhage with resultant pituitary infarct.

Sheehan’s syndrome

7. What is the syndrome where there is rapid growth in ACTH secreting pituitary tumours causing hyper pigmentation of the skin?

Nelson’s syndrome

8. Name the cell-organelle of beta cell of islets of Langerhan’s where insulin is synthesized

Rough endoplasmic reticulum

9. What is nonsuppressible insulin-like activity (NSILA)?

Anti-insulin antibodies that cannot suppress insulin-like activity

10. What is the half-life of insulin in circulation?

5 min

 

11. In severe diabetes mellitus, acetoacetic levels increase the hydrogen ions in plasma resulting in a peculiar breathing in the subject. What is this breathing?

Kussmaul breathing

12. Before the isolation of insulin principal treatment of human diabetes is the starvation diet. What is this regimen called?

Allen regimen

13. What is the alternate name for anti diuretic hormone?

Vasopressin

( UMS, 2008 )